Endocervical glandular dysplasia, adenocarcinoma in situ, and early invasive (microinvasive) adenocarcinoma of the uterine cervix

Abstract

The pathological features of endocervical glandular dysplasia (EGD), adenocarcinoma in situ (AIS), and early invasive (microinvasive) adenocarcinoma are reviewed. The histology and histochemistry of normal endocervical epithelium is discussed. The association of human papillomavirus (HPV) with the precursor lesions of invasive adenocarcinoma is examined. In the section on AIS, particular areas discussed include topography, immunohistochemistry, ploidy, and differential diagnosis. A management plan for AIS, EGD, and AIS with early invasion is presented.