Integration and visualization of host-pathogen data related to infectious diseases

Bioinformatics. 2011 Aug 15;27(16):2279-87. doi: 10.1093/bioinformatics/btr391. Epub 2011 Jun 27.


Motivation: Infectious disease research is generating an increasing amount of disparate data on pathogenic systems. There is a growing need for resources that effectively integrate, analyze, deliver and visualize these data, both to improve our understanding of infectious diseases and to facilitate the development of strategies for disease control and prevention.

Results: We have developed Disease View, an online host-pathogen resource that enables infectious disease-centric access, analysis and visualization of host-pathogen interactions. In this resource, we associate infectious diseases with corresponding pathogens, provide information on pathogens, pathogen virulence genes and the genetic and chemical evidences for the human genes that are associated with the diseases. We also deliver the relationships between pathogens, genes and diseases in an interactive graph and provide the geolocation reports of associated diseases around the globe in real time. Unlike many other resources, we have applied an iterative, user-centered design process to the entire resource development, including data acquisition, analysis and visualization.

Availability and implementation: Freely available at; all major web browsers supported.


Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Bacteria / pathogenicity
  • Bacterial Infections / microbiology
  • Communicable Diseases / epidemiology
  • Communicable Diseases / genetics
  • Communicable Diseases / microbiology*
  • Computational Biology
  • Computer Graphics
  • Databases, Factual*
  • Host-Pathogen Interactions*
  • Humans
  • Software
  • Systems Integration
  • Virulence