A primer on meiotic resumption in starfish oocytes: the proposed signaling pathway triggered by maturation-inducing hormone

Mol Reprod Dev. Oct-Nov 2011;78(10-11):704-7. doi: 10.1002/mrd.21343. Epub 2011 Jun 28.


This short review updates the maturation-inducing hormonal signaling in starfish oocytes. In this system, the activation of cyclin B-Cdc2 kinase (Cdk1) that leads to meiotic resumption does not require new protein synthesis. The key intracellular mediator after hormonal stimulation by 1-methyladenine is the protein kinase Akt/PKB, which in turn directly downregulates Myt1 and upregulates Cdc25 toward the activation of cyclin B-Cdc2. Mitotic kinases including Aurora, Plk1 and Greatwall are activated downstream of cyclin B-Cdc2. The starfish oocyte thus provides a simple model system for the study of meiotic resumption.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CDC2 Protein Kinase / metabolism
  • CDC2 Protein Kinase / physiology
  • Cyclin B / metabolism
  • Cyclin B / physiology
  • Female
  • Hormones / pharmacology
  • Maturation-Promoting Factor / pharmacology*
  • Meiosis / drug effects*
  • Meiosis / physiology
  • Models, Biological
  • Oocytes / drug effects*
  • Oocytes / metabolism
  • Oocytes / physiology
  • Signal Transduction / drug effects
  • Signal Transduction / genetics
  • Starfish / genetics*
  • Starfish / metabolism*


  • Cyclin B
  • Hormones
  • CDC2 Protein Kinase
  • Maturation-Promoting Factor