Warfarin glycosylation invokes a switch from anticoagulant to anticancer activity

ChemMedChem. 2011 Aug 1;6(8):1347-50. doi: 10.1002/cmdc.201100178. Epub 2011 Jun 28.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anticoagulants / chemical synthesis
  • Anticoagulants / chemistry*
  • Anticoagulants / pharmacology
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / toxicity
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Glycosides / chemical synthesis
  • Glycosides / chemistry
  • Glycosides / toxicity
  • Glycosylation
  • Humans
  • Mixed Function Oxygenases / antagonists & inhibitors
  • Mixed Function Oxygenases / metabolism
  • Stereoisomerism
  • Vitamin K Epoxide Reductases
  • Warfarin / analogs & derivatives*
  • Warfarin / chemical synthesis
  • Warfarin / toxicity

Substances

  • Anticoagulants
  • Antineoplastic Agents
  • Glycosides
  • Warfarin
  • Mixed Function Oxygenases
  • Vitamin K Epoxide Reductases