Regulation of Axonal Outgrowth and Pathfinding by integrin-ECM Interactions

Dev Neurobiol. 2011 Nov;71(11):901-23. doi: 10.1002/dneu.20931.

Abstract

Developing neurons use a combination of guidance cues to assemble a functional neural network. A variety of proteins immobilized within the extracellular matrix (ECM) provide specific binding sites for integrin receptors on neurons. Integrin receptors on growth cones associate with a number of cytosolic adaptor and signaling proteins that regulate cytoskeletal dynamics and cell adhesion. Recent evidence suggests that soluble growth factors and classic axon guidance cues may direct axon pathfinding by controlling integrin-based adhesion. Moreover, because classic axon guidance cues themselves are immobilized within the ECM and integrins modulate cellular responses to many axon guidance cues, interactions between activated receptors modulate cell signals and adhesion. Ultimately, growth cones control axon outgrowth and pathfinding behaviors by integrating distinct biochemical signals to promote the proper assembly of the nervous system. In this review, we discuss our current understanding how ECM proteins and their associated integrin receptors control neural network formation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Communication / physiology*
  • Growth Cones / chemistry
  • Growth Cones / physiology*
  • Humans
  • Integrins / chemistry
  • Integrins / physiology*
  • Nervous System / cytology
  • Nervous System / embryology*
  • Nervous System / growth & development*
  • Neural Pathways / chemistry
  • Neural Pathways / embryology
  • Neural Pathways / growth & development
  • Neurogenesis / physiology*
  • Signal Transduction / physiology

Substances

  • Integrins