Cananginones A–I, linear acetogenins from the stem bark of Miliusa velutina [corrected]

Nikhom Wongsa; Somdej Kanokmedhakul; Kwanjai Kanokmedhakul

doi:10.1016/j.phytochem.2011.05.013

Cananginones A–I, linear acetogenins from the stem bark of Miliusa velutina [corrected]

Phytochemistry. 2011 Oct;72(14-15):1859-64. doi: 10.1016/j.phytochem.2011.05.013. Epub 2011 Jun 27.

Authors

Nikhom Wongsa¹, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul

Affiliation

¹ Natural Products Research Unit, Department of Chemistry, Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.

PMID: 21714976
DOI: 10.1016/j.phytochem.2011.05.013

Abstract

Nine linear C23 and C21 acetogenins, named cananginones A-I (1-9), were isolated from stem bark of Miliusa velutina [corrected] . Their structures were established by spectroscopic methods. These compounds showed cytotoxicity against three cancer cell lines (KB, MCF7 and NCI-H187) with IC₅₀ values in the range 16.6-129.7 μM. Only 5 showed weak antimalarial activity against Plasmodium falciparum. In addition, 8 and 9 exhibited weak antifungal activity against Candida albicans.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetogenins / chemistry
Acetogenins / isolation & purification
Acetogenins / pharmacology*
Anti-Infective Agents / chemistry
Anti-Infective Agents / isolation & purification
Anti-Infective Agents / pharmacology*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Cananga / chemistry*
Candida albicans / drug effects
Cell Line, Tumor
Female
Humans
Inhibitory Concentration 50
Microbial Sensitivity Tests
Plant Bark / chemistry
Plant Extracts / chemistry*
Plant Stems / chemistry
Plasmodium falciparum / drug effects

Substances

Acetogenins
Anti-Infective Agents
Antineoplastic Agents, Phytogenic
Plant Extracts