Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans

Bioorg Med Chem. 2011 Nov 15;19(22):6654-7. doi: 10.1016/j.bmc.2011.05.041. Epub 2011 May 27.

Abstract

The antifungal spirocyclic guanidine alkaloid, ptilomycalin A, from marine sponge Monanchora arbuscula, inhibits melanogenesis of Cryptococcus neoformans in vitro through inhibition of biosynthesis of laccase in the melanin biosynthetic pathway with an IC(50) of 7.3 μM.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antifungal Agents / pharmacology
  • Cryptococcosis / microbiology
  • Cryptococcus neoformans / drug effects*
  • Cryptococcus neoformans / enzymology
  • Cryptococcus neoformans / metabolism*
  • Enzyme Inhibitors / pharmacology
  • Guanidines / pharmacology*
  • Laccase / antagonists & inhibitors*
  • Laccase / metabolism
  • Melanins / biosynthesis*
  • Porifera / chemistry

Substances

  • Antifungal Agents
  • Enzyme Inhibitors
  • Guanidines
  • Melanins
  • ptilomycalin A
  • Laccase