FGF modulates the PDGF-driven pathway of oligodendrocyte development

Neuron. 1990 Nov;5(5):603-14. doi: 10.1016/0896-6273(90)90215-2.


PDGF promotes the growth of oligodendrocyte type-2 astrocyte (O-2A) glial progenitor cells and allows their timely differentiation into oligodendrocytes, the CNS myelin-forming cells. We demonstrate that basic FGF is a potent mitogen for brain O-2A progenitor cells, but blocks their differentiation into oligodendrocytes. Treatment with basic FGF also influences the level of expression of PDGF receptors on O-2A progenitor cells. These cells express only the alpha chain PDGF receptor, and the levels of PDGF alpha receptors decrease as the cells differentiate. In contrast, basic FGF maintains a high level of functionally responsive PDGF alpha receptors in O-2A progenitors. Thus basic FGF activates a signaling pathway that can positively regulate PDGF receptors in O-2A progenitor cells. In this way basic FGF or an FGF-like factor may modulate the production of myelin-forming cells in the CNS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Astrocytes / physiology
  • Brain / cytology
  • Brain / metabolism
  • Cell Differentiation / drug effects
  • DNA / biosynthesis
  • Fibroblast Growth Factor 2 / pharmacology
  • Fibroblast Growth Factor 2 / physiology*
  • Homeostasis
  • Neuroglia / physiology
  • Oligodendroglia / physiology*
  • Platelet-Derived Growth Factor / physiology*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism
  • Receptors, Platelet-Derived Growth Factor
  • Stem Cells / cytology
  • Stem Cells / metabolism
  • Transcription, Genetic


  • Platelet-Derived Growth Factor
  • Receptors, Cell Surface
  • Fibroblast Growth Factor 2
  • DNA
  • Receptors, Platelet-Derived Growth Factor