Copper-catalyzed oxidative direct cyclization of N-methylanilines with electron-deficient alkenes using molecular oxygen

J Org Chem. 2011 Aug 5;76(15):6447-51. doi: 10.1021/jo2011329. Epub 2011 Jul 11.

Abstract

The oxidative direct cyclizaion of N-methylanilines with electron-deficient alkenes involving maleimides and benzylidene malononitriles through sp(3) and sp(2) C-H bond cleavage proceeds effectively under a CuCl(2)/O(2) catalysis to provide the corresponding tetrahydroquinolines in good yields.