Oxidative stress, inflamm-aging and immunosenescence

J Proteomics. 2011 Oct 19;74(11):2313-23. doi: 10.1016/j.jprot.2011.06.005. Epub 2011 Jun 21.


Immunosenescence is characterized by a decreased ability of the immune system to respond to foreign antigens, as well as a decreased ability to maintain tolerance to self-antigens. This results in an increased susceptibility to infection and cancer and reduced responses to vaccination [1-5]. The mechanisms underlying immunosenescence comprise a series of cellular and molecular events involving alteration of several biochemical pathways and different cellular populations, and for the most part our understanding of these molecular mechanisms is still fragmentary. In this review we will focus on the process of senescence associated with oxidative stress, in particular how protein oxidation alters the functionality of immune cells and how oxidative stress contributes to a chronic inflammatory process often referred as inflamm-aging.

Publication types

  • Review

MeSH terms

  • Aging / immunology*
  • Aging / metabolism
  • Animals
  • Cellular Senescence / immunology*
  • Humans
  • Immune System / metabolism
  • Immune System / physiology*
  • Inflammation / immunology
  • Inflammation / metabolism*
  • Models, Biological
  • Nitrosation / physiology
  • Oxidative Stress / immunology
  • Oxidative Stress / physiology*
  • Protein Carbonylation / physiology
  • Protein Processing, Post-Translational