[Radioembolization with (90)Y-labeled microspheres: post-therapeutic therapy validation with Bremsstrahlung-SPECT]

Z Med Phys. 2011 Dec;21(4):274-80. doi: 10.1016/j.zemedi.2011.05.002. Epub 2011 Jun 29.
[Article in German]


During the last years angiographic Selective Internal Radiotherapy (SIRT) with (90)Y-labelled microspheres has become a common technique for the local-ablative treatment of cancer patients. SIRT is a palliative therapy concept for the treatment of liver malignancies. As a result of (90)Y-decay as β(-)-emitter without a concomitant gamma radiation, Bremsstrahlung imaging is needed to validate the distribution achieved by radioembolisation. This article demonstrates the method of imaging through phantom measurement and shows the advantages of post-therapeutic tomography by means of a patient study. Approaches for further optimization of Bremsstrahlung imaging are discussed.

Publication types

  • English Abstract

MeSH terms

  • Body Burden
  • Dose-Response Relationship, Radiation
  • Embolization, Therapeutic / methods*
  • Humans
  • Liver / blood supply
  • Liver Neoplasms / radiotherapy*
  • Microspheres
  • Palliative Care*
  • Phantoms, Imaging
  • Radiotherapy Planning, Computer-Assisted / methods*
  • Tomography, Emission-Computed, Single-Photon / methods*
  • Treatment Outcome
  • Yttrium Radioisotopes / pharmacokinetics
  • Yttrium Radioisotopes / therapeutic use*


  • Yttrium Radioisotopes