The National Emphysema Treatment Trial (NETT) Part II: Lessons learned about lung volume reduction surgery

Am J Respir Crit Care Med. 2011 Oct 15;184(8):881-93. doi: 10.1164/rccm.201103-0455CI.


Substantial information regarding the role of lung volume reduction surgery (LVRS) in severe emphysema emanates from the National Emphysema Treatment Trial (NETT). The NETT was not a crossover trial and therefore was able to examine the effects of optimal medical management and LVRS on short- and long-term survival,as well as lung function, exercise performance, and quality of life.The NETT generated multiple insights into the preoperative, perioperative,and postoperative management of patients undergoing thoracotomy; described pain control techniques that were safe and effective; and emphasized the need to address nonpulmonary issues to optimize surgical outcomes. After the NETT, newer investigation has focused on bronchoscopic endobronchial interventions and other techniques less invasive than LVRS to achieve lung reduction.In this review, we summarize what we currently know about the role of LVRS in the treatment of severe emphysema as a result of insights gained from the NETT and provide a brief review of the newer techniques of lung volume reduction.

Publication types

  • Review

MeSH terms

  • Cost-Benefit Analysis
  • Humans
  • Pneumonectomy / economics
  • Pneumonectomy / methods*
  • Pneumonectomy / mortality
  • Pulmonary Emphysema / mortality
  • Pulmonary Emphysema / surgery*
  • Quality of Life
  • Risk Factors
  • Survival Rate