The biological activity of retinoids in melanoma cells. Induction of expression of retinoic acid receptor-beta by retinoic acid in S91 melanoma cells

FEBS Lett. 1990 Oct 29;273(1-2):19-22. doi: 10.1016/0014-5793(90)81041-l.

Abstract

The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-alpha and RAR-gamma was unaffected by retinoic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carrier Proteins / biosynthesis
  • Carrier Proteins / genetics*
  • Cell Line
  • Cycloheximide / pharmacology
  • Gene Expression / drug effects*
  • Kinetics
  • Melanoma, Experimental
  • Mice
  • RNA, Messenger / genetics
  • RNA, Messenger / isolation & purification
  • Receptors, Retinoic Acid
  • Stereoisomerism
  • Tretinoin / analogs & derivatives
  • Tretinoin / pharmacology*

Substances

  • Carrier Proteins
  • RNA, Messenger
  • Receptors, Retinoic Acid
  • 3,4-didehydroretinoic acid
  • Tretinoin
  • Cycloheximide