Abstract
The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-alpha and RAR-gamma was unaffected by retinoic acid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carrier Proteins / biosynthesis
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Carrier Proteins / genetics*
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Cell Line
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Cycloheximide / pharmacology
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Gene Expression / drug effects*
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Kinetics
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Melanoma, Experimental
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Mice
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RNA, Messenger / genetics
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RNA, Messenger / isolation & purification
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Receptors, Retinoic Acid
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Stereoisomerism
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Tretinoin / analogs & derivatives
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Tretinoin / pharmacology*
Substances
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Carrier Proteins
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RNA, Messenger
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Receptors, Retinoic Acid
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3,4-didehydroretinoic acid
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Tretinoin
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Cycloheximide