IL-17 in spondyloarthritis: is the T-party over?

Arthritis Res Ther. 2011 Jun 24;13(3):115. doi: 10.1186/ar3351.


The past decade has witnessed significant progress in revealing an important role for IL-17 in the pathogenesis of several immune-mediated inflammatory diseases. Recent studies have provided new insights into the cellular source of IL-17, originally identified as the signature cytokine of a distinct CD4(+) T-cell subset known as Th17. Accumulating evidence suggests that the majority of the IL-17 released in inflammatory arthritis is produced by innate immune cells rather than T cells. Understanding molecular mechanisms behind these early innate immune responses will be the key to designing rational therapies targeting these important inflammatory pathways.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Adaptive Immunity / immunology*
  • Humans
  • Interleukin-17 / immunology*
  • Spondylitis, Ankylosing / immunology*
  • Th17 Cells / immunology*
  • Zygapophyseal Joint / immunology*


  • IL17A protein, human
  • Interleukin-17