The Obesity Phenotype in Children With Asthma

Paediatr Respir Rev. 2011 Sep;12(3):152-9. doi: 10.1016/j.prrv.2011.01.009. Epub 2011 Mar 4.

Abstract

Asthma and obesity have been increasing in prevalence internationally among children. Evidence points to an association between these chronic morbidities, suggesting the development of an 'obese asthma' phenotype in childhood. This review summarises the evidence that the proinflammatory environment created by excess adiposity may provide a mechanism leading to obese asthma in children and adolescents. Weight loss studies conducted in children without asthma have demonstrated a reduction in systemic inflammation. However, the impact of weight loss in the obese paediatric population with asthma has not been investigated. The paucity of information highlights the need for high quality randomised controlled trials of weight loss in this population that include assessment of systemic and airway inflammation, and clinical asthma outcomes. This will lead to refinements in management approaches for these patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adiponectin / metabolism
  • Adolescent
  • Asthma / epidemiology
  • Asthma / etiology
  • Asthma / immunology
  • Asthma / physiopathology*
  • C-Reactive Protein / metabolism
  • Child
  • Comorbidity
  • Humans
  • Inflammation / epidemiology
  • Inflammation / etiology
  • Inflammation / immunology
  • Inflammation / physiopathology
  • Leptin / metabolism
  • Obesity / complications
  • Obesity / epidemiology
  • Obesity / immunology
  • Obesity / physiopathology*
  • Phenotype
  • Tumor Necrosis Factor-alpha / metabolism
  • Weight Loss

Substances

  • Adiponectin
  • Leptin
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein