New insights in plant immunity signaling activation

Curr Opin Plant Biol. 2011 Oct;14(5):512-8. doi: 10.1016/j.pbi.2011.05.005. Epub 2011 Jun 29.


Plant disease resistance can be triggered by specific recognition of microbial effectors by plant nucleotide binding-leucine rich repeat (NB-LRR) receptors. Over the last few years, many efforts have greatly improved the understanding of effector and NB-LRR function, but have left a lot of questions as to how effector perception activates NB-LRR induction of defense signaling. This review describes exciting new findings showing similarities and differences in function of diverse plant NB-LRR proteins in terms of pathogen recognition and where and how resistance proteins are activated. Localization studies have shown that some NB-LRRs can activate signaling from the cytosol while others act in the nucleus. Also, the structural determination of two NB-LRR signaling domains demonstrated that receptor oligomerization is fundamental for the activation of resistance signaling.

Publication types

  • Review

MeSH terms

  • Defense Mechanisms
  • Disease Resistance
  • Plant Diseases / immunology*
  • Plant Immunity / physiology*
  • Plant Proteins / immunology*
  • Signal Transduction


  • Plant Proteins