Thiazolidinediones regulate adipose lineage dynamics

Cell Metab. 2011 Jul 6;14(1):116-22. doi: 10.1016/j.cmet.2011.05.012.


White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacologic stimuli affect such plasticity. Combining in vivo lineage marking and BrdU labeling strategies, we found that rosiglitazone, a member of the thiazolidinedione class of glucose-lowering medicines, markedly increases the evolution of adipose progenitors into adipocytes. Notably, chronic rosiglitazone administration disrupts the adipogenic and self-renewal capacities of the stem cell compartment and alters its molecular characteristics. These data unravel unknown aspects of adipose dynamics and provide a basis to manipulate the adipose lineage for therapeutic ends.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes / cytology
  • Adipocytes / metabolism
  • Adipose Tissue, White / cytology*
  • Adipose Tissue, White / drug effects
  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Cell Proliferation
  • Mice
  • Stem Cells / cytology
  • Stem Cells / metabolism
  • Thiazolidinediones / pharmacology*


  • Thiazolidinediones

Associated data

  • GEO/GSE30116