Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism

Semin Immunol. 2011 Dec;23(6):431-7. doi: 10.1016/j.smim.2011.06.002. Epub 2011 Jul 2.


Foxp3+CD4+ regulatory T (T(reg)) cells are a key population in controlling the immune response. Recently, their roles have been expanded to broader, non-immune, contexts, in particular the metabolic consequences downstream of obesity-induced inflammation, e.g. type-2 diabetes and cardiovascular disease. This review highlights the major innate and adaptive immune cell subsets contributing to adipose-tissue inflammation, the key role played by fat-resident T(regs), and the potential of T(reg)-based therapies for treatment of the metabolic syndrome.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adipose Tissue / immunology*
  • Adipose Tissue / metabolism
  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • Diabetes Mellitus, Type 2 / immunology
  • Forkhead Transcription Factors / immunology*
  • Humans
  • Obesity / immunology
  • T-Lymphocytes, Regulatory / immunology*


  • Forkhead Transcription Factors