Iron homeostasis--Achilles' heel of Aspergillus fumigatus?

Curr Opin Microbiol. 2011 Aug;14(4):400-5. doi: 10.1016/j.mib.2011.06.002. Epub 2011 Jul 1.


The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by upregulation of iron uptake mechanisms including siderophore biosynthesis and downregulation of iron-consuming pathways to spare iron. These metabolic changes depend mainly on the transcription factor HapX. Consistent with the crucial role of iron in pathophysiology, genetic inactivation of either HapX or the siderophore system attenuates virulence of A. fumigatus in a murine model of aspergillosis. The differences in iron handling between mammals and fungi might serve to improve therapy and diagnosis of fungal infections.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Aspergillosis / microbiology
  • Aspergillus fumigatus / genetics
  • Aspergillus fumigatus / metabolism*
  • Aspergillus fumigatus / pathogenicity
  • Gene Expression Regulation, Fungal
  • Homeostasis*
  • Host-Pathogen Interactions
  • Humans
  • Iron / metabolism*
  • Molecular Structure
  • Oxidative Stress
  • Siderophores / biosynthesis*
  • Siderophores / chemistry
  • Spores, Fungal / metabolism
  • Transcription, Genetic
  • Transcriptional Activation
  • Virulence


  • Siderophores
  • Iron