Functional ultrasound imaging of the brain

Nat Methods. 2011 Jul 3;8(8):662-4. doi: 10.1038/nmeth.1641.


We present functional ultrasound (fUS), a method for imaging transient changes in blood volume in the whole brain at better spatiotemporal resolution than with other functional brain imaging modalities. fUS uses plane-wave illumination at high frame rate and can measure blood volumes in smaller vessels than previous ultrasound methods. fUS identifies regions of brain activation and was used to image whisker-evoked cortical and thalamic responses and the propagation of epileptiform seizures in the rat brain.

MeSH terms

  • Algorithms*
  • Animals
  • Brain / physiopathology*
  • Brain Mapping / methods*
  • Evoked Potentials*
  • Image Interpretation, Computer-Assisted / methods*
  • Rats
  • Ultrasonography / methods*