Infectious mononucleosis and related syndromes

Am J Med Sci. Nov-Dec 1978;276(3):325-39. doi: 10.1097/00000441-197811000-00010.

Abstract

The "mono syndrome" is an acute febrile disease of older children and young adults which involves the lymphatic system and is characterized hematologically by the presence of 50% or more lymphocytes and monocytes and 10% or more atypical lymphocytes. Epstein-Barr virus (EBV) causes over 90% of the syndrome, cytomegalovirus (CMV) about 5% to 7%, and Toxoplasma gondii less than 1%. Viral hepatitis, adenovirus, rubella, and herpes simplex are rare causes. Only EBV produces classical heterophile-positive infectious mononucleosis. This article reviews the epidemiological and clinical features of this syndrome.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Antibodies / analysis
  • Antibodies, Viral / analysis
  • Child
  • Child, Preschool
  • Cricetinae
  • Cytomegalovirus / immunology
  • Diagnosis, Differential
  • Female
  • Herpesvirus 4, Human / immunology
  • Humans
  • Infant
  • Infant, Newborn
  • Infectious Mononucleosis / diagnosis*
  • Infectious Mononucleosis / epidemiology
  • Infectious Mononucleosis / etiology
  • Leukocyte Count
  • Male
  • Monocytes
  • Pregnancy
  • Syndrome
  • Toxoplasma / immunology
  • Transfusion Reaction

Substances

  • Antibodies
  • Antibodies, Viral