Low Mannose-Binding Lectin (MBL) genotype is associated with future cardiovascular events in type 2 diabetic South Asians. A prospective cohort study

Cardiovasc Diabetol. 2011 Jul 5;10:60. doi: 10.1186/1475-2840-10-60.

Abstract

Background: South Asians have a high burden of type 2 diabetes and vascular complications. Vascular inflammation is considered central in the pathophysiology of atherosclerosis, and the complement system is thought to play an important role. Mannose-Binding Lectin (MBL), which activates the lectin pathway of complement activation, has been introduced as a risk marker of vascular damage. The present study explores the association of MBL levels, genotype and cardiovascular events in type 2 diabetic South Asians.

Methods: We conducted a prospective observational study. A cohort consisting of 168 type 2 diabetic South Asians was followed for a median duration of 7.66 years. At baseline, MBL levels and genotype were determined. The association with future cardiovascular events was assessed by Cox proportional hazard regression.

Results: During follow-up, 31 cardiovascular events occurred in 22 subjects (11 men, 11 women). The O/O genotype was significantly associated with the occurrence of cardiovascular events (hazard ratio 3.42, 95%CI 1.24-9.49, P = 0.018). However, log MBL levels were not associated with the occurrence of cardiovascular events (hazard ratio 0.93, 95% CI 0.50-1.73).

Conclusions: In type 2 diabetic South Asians, the O/O MBL genotype is associated with cardiovascular events, although single serum MBL levels are not.

MeSH terms

  • Adult
  • Angioplasty, Balloon, Coronary
  • Asia, Southeastern / epidemiology
  • Cardiovascular Diseases / epidemiology*
  • Cardiovascular Diseases / ethnology*
  • Cardiovascular Diseases / genetics
  • Cohort Studies
  • Complement System Proteins / metabolism
  • Coronary Artery Bypass
  • Death, Sudden, Cardiac / epidemiology
  • Death, Sudden, Cardiac / ethnology
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications*
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease / genetics*
  • Genotype*
  • Humans
  • Incidence
  • Kaplan-Meier Estimate
  • Longitudinal Studies
  • Male
  • Mannose-Binding Lectin / blood
  • Mannose-Binding Lectin / genetics*
  • Middle Aged
  • Myocardial Infarction / epidemiology
  • Myocardial Infarction / ethnology
  • Myocardial Infarction / genetics
  • Prospective Studies

Substances

  • Mannose-Binding Lectin
  • Complement System Proteins