Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jun 17;3:RRN1242.
doi: 10.1371/currents.RRN1242.

Assessment of Depression, Anxiety and Apathy in Prodromal and Early Huntington Disease

Affiliations
Free PMC article

Assessment of Depression, Anxiety and Apathy in Prodromal and Early Huntington Disease

Anthony L Vaccarino et al. PLoS Curr. .
Free PMC article

Abstract

The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identify relevant symptom domains, including HD individuals, caregivers, and experts from a variety of fields, as well as knowledge gained from the analysis of data from ongoing large-scale studies in HD using existing clinical scales. This is an iterative process in which an ongoing series of field tests in prodromal (prHD) and early HD individuals provides the team with data on which to make decisions regarding which questions should undergo further development or testing and which should be excluded. We report here the development and assessment of the first iteration of interview questions aimed to assess Depression, Anxiety and Apathy in prHD and early HD individuals.

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles

References

    1. Evans K, K Anderson, B Borowsky, J Giuliano, M Guttman, A Ho, J Paulsen, T Sills, A Vaccarino, D van Kammen, And the FuRST-pHD, PREDICT-HD Investigators and Coordinators. The Functional Rating Scale Taskforce for pre-Huntington Disease: Results So Far, J Neurol Neurosurg Psychiatry 2010; 81:A25
    1. Duff K, Paulsen JS, Beglinger LJ, Langbehn DR, Stout JC; Predict-HD Investigators of the Huntington Study Group. Psychiatric symptoms in Huntington's disease before diagnosis: the Predict-HD study. Biol Psychiatry. 2007;62(12):1341-6. - PubMed
    1. Vaccarino, A.L., M. Bagby, PhD, K.R. Evans, J.Ferguson, A.H. Kalali, S.H. Kennedy, K. Kobak, J. Kwentus, D. Santor, T.L. Sills, J.B.Williams, G. Wunderlich, And the Depression Inventory Development Team. The Depression Inventory Development Initiative: results from the second validation study, New Clinical Drug Evaluation Unit Abstracts, 2008.
    1. Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research, Center for Devices and Radiological Health Guidance for Industry, Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims. U.S. Dept of Health and Human Services Food and Drug Administration, December, 2009. - PMC - PubMed
    1. Williams JBW, Kobak KA, Bech P, et al. The GRID-HAMD: Standardization of the Hamilton Depression Rating Scale. Int Clin Psychopharm 2008;23:120-129 - PubMed
Feedback