Connecting the nanodots: programmable nanofabrication of fused metal shapes on DNA templates

Nano Lett. 2011 Aug 10;11(8):3489-92. doi: 10.1021/nl202066c. Epub 2011 Jul 12.


We present a novel method for producing complex metallic nanostructures of programmable design. DNA origami templates, modified to have DNA binding sites with a uniquely coded sequence, were adsorbed onto silicon dioxide substrates. Gold nanoparticles functionalized with the cDNA sequence were then attached. These seed nanoparticles were later enlarged, and even fused, by electroless deposition of silver. Using this method, we constructed a variety of metallic structures, including rings, pairs of bars, and H shapes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • DNA / chemistry*
  • Gold / chemistry
  • Metal Nanoparticles*
  • Templates, Genetic*


  • Gold
  • DNA