NLRP3 inflammasomes link inflammation and metabolic disease

Trends Immunol. 2011 Aug;32(8):373-9. doi: 10.1016/ Epub 2011 Jul 4.


A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins / immunology*
  • Humans
  • Immunotherapy* / trends
  • Inflammasomes / immunology*
  • Inflammation
  • Interleukin-18 / immunology
  • Interleukin-1beta / immunology*
  • Metabolic Diseases / drug therapy
  • Metabolic Diseases / immunology*
  • Molecular Targeted Therapy
  • NLR Family, Pyrin Domain-Containing 3 Protein


  • Carrier Proteins
  • Inflammasomes
  • Interleukin-18
  • Interleukin-1beta
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human