Development of newborn and infant vaccines

Sci Transl Med. 2011 Jul 6;3(90):90ps27. doi: 10.1126/scitranslmed.3001880.


Vaccines for early-life immunization are a crucial biomedical intervention to reduce global morbidity and mortality, yet their developmental path has been largely ad hoc, empiric, and inconsistent. Immune responses of human newborns and infants are distinct and cannot be predicted from those of human adults or animal models. Therefore, understanding and modeling age-specific human immune responses will be vital to the rational design and development of safe and effective vaccines for newborns and infants.

Publication types

  • Research Support, American Recovery and Reinvestment Act
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Child, Preschool
  • Communicable Disease Control
  • Humans
  • Immune System / immunology*
  • Infant, Newborn / immunology*
  • Vaccination
  • Vaccines / immunology*


  • Vaccines