Positive outcomes of oil palm phenolics on degenerative diseases in animal models

Br J Nutr. 2011 Dec;106(11):1664-75. doi: 10.1017/S0007114511002133. Epub 2011 Jun 7.


It is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbits fed an atherogenic diet. In Nile rats, a spontaneous model of the metabolic syndrome and type 2 diabetes, OPP protected against multiple aspects of the syndrome and diabetes progression. In tumour-inoculated mice, OPP protected against cancer progression. Microarray studies on the tumours showed differential transcriptome profiles that suggest anti-tumour molecular mechanisms involved in OPP action. Thus, initial studies suggest that OPP may have potential against several chronic disease outcomes in mammals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arrhythmias, Cardiac / prevention & control
  • Atherosclerosis / prevention & control
  • Blood Pressure
  • Diabetes Mellitus, Type 2 / prevention & control
  • Disease Models, Animal*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Nitric Oxide / deficiency
  • Palm Oil
  • Phenols / therapeutic use*
  • Plant Oils / chemistry
  • Plant Oils / therapeutic use*
  • Rabbits
  • Rats
  • Rats, Inbred WKY


  • Phenols
  • Plant Oils
  • Nitric Oxide
  • Palm Oil