Inhibition by wheat sprout (Triticum aestivum) juice of bisphenol A-induced oxidative stress in young women

Mutat Res. 2011 Sep 18;724(1-2):64-8. doi: 10.1016/j.mrgentox.2011.06.007. Epub 2011 Jun 28.


For health of future generation, fertile young women should be monitored for exposure of endocrine disrupting chemicals (EDCs). Among EDCs, bisphenol A (BPA) is suggested to induce reactive oxygen species (ROS) which play an important role in pathologies of female diseases such as endometriosis. On the other hand, previous studies suggested that sprouts of wheat (Triticum aestivum) have antimutagenicity and antioxidant activity. We performed the 2 weeks intervention of wheat sprout juice (100ml/day) to investigate its effects on BPA-exposure and -oxidative toxicity in young women (N=14, age=24.4±4.0). Geometrical mean of urinary BPA levels was 1.81 (GSTD, 4.34)μg/g creatinine. We observed that irregular meals significantly increased levels of urinary BPA approximate 3 times (p=0.03). In addition, we found BPA-induced oxidative stress is correlated with levels of 8-hydroxydeoxyguanosine (8-OHdG) or malondialdehyde (MDA) levels (p=0.18 or 0.03, respectively). We also observed a continuous reduction of urinary BPA during the wheat sprout intervention (p=0.02). In summary, our data suggested potential detoxification of wheat sprouts on BPA-toxicity via antioxidative and interference of absorption, distribution, metabolism and excretion (ADME)-mediated mechanisms in young women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / pharmacology*
  • Benzhydryl Compounds
  • DNA Damage / drug effects
  • Endocrine Disruptors / pharmacology*
  • Female
  • Humans
  • Oxidative Stress / drug effects*
  • Phenols / antagonists & inhibitors
  • Phenols / pharmacology*
  • Phenols / urine
  • Plant Extracts / pharmacology*
  • Reactive Oxygen Species / metabolism
  • Triticum / chemistry*
  • Young Adult


  • Antioxidants
  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Phenols
  • Plant Extracts
  • Reactive Oxygen Species
  • bisphenol A