Dependence of cell survival on instantaneous dose rate of a linear accelerator

Radiother Oncol. 2011 Oct;101(1):223-5. doi: 10.1016/j.radonc.2011.06.018. Epub 2011 Jul 5.


Background and purpose: With the development of flattening filter-free linear accelerators for radiotherapy, the instantaneous dose rate has increased by approximately a factor 4. This leads to the question of whether there may be a radiobiological consequence. The present study investigates the radiobiological effect of this high instantaneous dose rate on two cell lines.

Materials and methods: A Varian Trilogy TX linear accelerator was used to directly compare the effect of three different dose rates (5.01, 9.99 and 29.91 Gy/min, with instantaneous dose rates in the pulse of 56.5, 112.8 and 338 Gy/s) on clonogenic survival. V79 and FaDu(DD) cells were irradiated with doses in a range from 1 to 10 Gy in order to obtain dose response curves.

Results: For both cell lines, there is not observed any effect of the instantaneous dose rate on cell survival.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival / radiation effects*
  • Cricetinae
  • Dose-Response Relationship, Radiation
  • Humans
  • Particle Accelerators*
  • Radiation Dosage
  • Radiation, Ionizing*
  • Radiobiology
  • Sensitivity and Specificity
  • Tumor Cells, Cultured / radiation effects