Traversing the NPC along the pore membrane: targeting of membrane proteins to the INM

Nucleus. Mar-Apr 2011;2(2):87-91. doi: 10.4161/nucl.2.2.14637.


The inner nuclear membrane (INM) accommodates a specific set of integral membrane proteins many of which interact with chromatin and/or in metazoan cells with the lamina network. The localization of these proteins characterizes this membrane area of the nuclear envelope (NE) despite the fact that the INM forms a membrane continuum with the outer nuclear membrane (ONM) and the remaining endoplasmic reticulum (ER). In fact, the INM can be regarded as a highly specialized membrane subdomain of the ER. How the specific protein composition of the INM is established and maintained and whether this is achieved via a single unifying mechanism is by and large unclear. Recent experiments shed light on some aspects of the process.

Keywords: Nup188; SUN2; inner nuclear membrane; membrane targeting; nuclear envelope; nuclear localization signal; nuclear pore complex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Membrane Proteins / metabolism*
  • Nuclear Pore / metabolism*
  • Protein Binding
  • Protein Transport


  • Membrane Proteins