Expression of the chloramphenicol acetyltransferase (CAT) reporter gene by the murine Cyp1a-2 (cytochrome P3(450)) promoter in hepatoma cell cultures

Biochem Biophys Res Commun. 1990 Nov 15;172(3):1109-15. doi: 10.1016/0006-291x(90)91561-6.

Abstract

In C57BL/6 mouse liver, both murine Cypla-1 (cytochrome P1(450] and Cypla-2 (P3(450] genes are inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin), and Cypla-2 is constitutively expressed at high levels. Although the Cypla-1 gene is constitutively expressed and TCDD-inducible in mouse hepatoma Hepa-1 cell cultures, Cypla-2 gene expression is absent in these cultures. We show here that the 5' flanking region of Cyp1a-2 from - 1843 to +52 (base pairs relative to the Transcription initiation site) linked to the chloramphenicol acetyltransferase (CAT) reporter gene in stable Hepa-1 transformants produces no basal or TCDD- or cycloheximide-inducible CAT activity. On the other hand, the Cyp1a-2 promoter from -63 to +52 driving the CAT gene is inducible by cycloheximide. A chimeric plasmid containing the Cyp1a-1 TCDD-responsive enhancer (-1646 to -245) ligated to a Cyp1a-2 promoter region (-129 to +52) supports TCDD-inducible CAT expression in Hepa-1 cells and in rat 7777 cells. These data suggest that, although sequences between - 1843 and +52 +52 are not sufficient for Cyp1a-2 gene expression, the murine Cyp1a-2 promoter is functional in cell cultures.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Carcinoma, Hepatocellular / enzymology
  • Carcinoma, Hepatocellular / genetics*
  • Cell Transformation, Neoplastic
  • Chloramphenicol O-Acetyltransferase / genetics*
  • Cytochrome P-450 Enzyme System / biosynthesis
  • Cytochrome P-450 Enzyme System / genetics*
  • Gene Expression Regulation, Enzymologic* / drug effects
  • Mice
  • Mice, Inbred C57BL / genetics*
  • Plasmids
  • Promoter Regions, Genetic*
  • Tetradecanoylphorbol Acetate / pharmacology
  • Tumor Cells, Cultured

Substances

  • Cytochrome P-450 Enzyme System
  • Chloramphenicol O-Acetyltransferase
  • Tetradecanoylphorbol Acetate