Origins of CD4(+) effector and central memory T cells

Nat Immunol. 2011 Jun;12(6):467-71. doi: 10.1038/ni.2038.


Lineage-committed effector CD4(+) T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (T(H)1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the T(H)2 cell, T(H)17 helper T cell, follicular helper T cell (T(FH) cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / immunology*
  • Dendritic Cells / immunology
  • Humans
  • Immunologic Memory / immunology*
  • Models, Immunological
  • T-Lymphocytes, Regulatory / immunology
  • Th1 Cells / immunology*
  • Th17 Cells / immunology*