Risk estimation for a malignant transformation of oral lesions by S100A7 and Doc-1 gene expression

Cancer Invest. 2011 Aug;29(7):478-84. doi: 10.3109/07357907.2011.597813.


The objective of this study was the correlation of Doc-1- and S100A7-gene expression in common oral lesions with their cancerous-transformation risk. Biopsies (n = 15 each) of healthy gingiva, irritation fibromas, leukoplakias and Oral squamous cell carcinoma (OSCCs) were obtained, and after RNA-extraction, transcripts of Doc-1 and S100A7 were quantified by RT-PCR. In comparison with the healthy gingiva, the expression of Doc-1 was decreased, whereas the expression of S100A7 was upregulated in all lesions. As the extent of Doc-1-inactivation and S100A7-overexpression is correlated with their biological behavior, the combined investigation of both genes could be a promising marker in intraoral lesions to estimate the risk for their malignant transformation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / pathology
  • Cell Transformation, Neoplastic*
  • Female
  • Fibroma / genetics*
  • Fibroma / pathology
  • Humans
  • Leukoplakia, Oral / genetics*
  • Leukoplakia, Oral / pathology
  • Male
  • Mouth Neoplasms / genetics*
  • Mouth Neoplasms / pathology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Risk
  • S100 Calcium Binding Protein A7
  • S100 Proteins / genetics*
  • Tumor Suppressor Proteins / genetics*


  • CDK2AP1 protein, human
  • S100 Calcium Binding Protein A7
  • S100 Proteins
  • S100A7 protein, human
  • Tumor Suppressor Proteins