Applications of leukocyte- and platelet-rich plasma (L-PRP) in trauma surgery

Curr Pharm Biotechnol. 2012 Jun;13(7):1173-84. doi: 10.2174/138920112800624445.

Abstract

Leukocyte- and platelet-rich plasma (L-PRP) contains high concentrations of platelet, leukocytes and other bioactivities, which play an prominent role in both bone and soft tissue healing processes. Large numbers of studies provide evidence for application of L-PRP in experiments and clinical practice. It has been identified to improve cellular chemotaxis, proliferation and differentiation, angiogenesis, and production of extracellular matrix, but also responsible for stimulating defense mechanisms against infections. L-PRP is now playing an increasing role in the management of patients with traumatic injuries. However, most studies are only anecdotal or case reports, and then larger controlled studies are needed. This article introduces the reader to L-PRP properties and L-PRP applications in trauma surgery, including applications of L-PRP in bone healing, acute soft tissue wound healing, and repairing of acute muscle, tendon, ligament, nerve and cartilage injury caused by trauma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Leukocytes / physiology*
  • Platelet-Rich Plasma / physiology*
  • Wound Healing / physiology*
  • Wounds and Injuries / physiopathology*
  • Wounds and Injuries / therapy*