Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model

ASN Neuro. 2011 Aug 3;3(3):e00063. doi: 10.1042/AN20110014.


GBM (glioblastoma multiforme) is a highly aggressive brain tumour with very poor prognosis despite multi-modalities of treatment. Furthermore, recent failure of targeted therapy for these tumours highlights the need of appropriate rodent models for preclinical studies. In this review, we highlight the most commonly used rodent models (U251, U86, GL261, C6, 9L and CNS-1) with a focus on the pathological and genetic similarities to the human disease. We end with a comprehensive review of the CNS-1 rodent model.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Brain Neoplasms / genetics
  • Brain Neoplasms / pathology*
  • Cell Line, Tumor
  • Clinical Trials as Topic
  • Disease Models, Animal*
  • Glioblastoma / genetics
  • Glioblastoma / pathology*
  • Humans