Protective effect of Diyarbakır watermelon juice on carbon tetrachloride-induced toxicity in rats

Food Chem Toxicol. 2011 Sep;49(9):2433-8. doi: 10.1016/j.fct.2011.06.064. Epub 2011 Jun 28.


The present study was designed to evaluate the effect of Diyarbakır watermelon (Citrullus lanatus cv. Sürme) juice on lipid peroxidation states in rat liver, kidney and brain. In vivo administration of carbon tetrachloride (CCl(4)) once a week for 28 days caused a significant elevation of serum markers of liver damage, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TB) and decrease in albumin when compared to the control group. However, administration of carbon tetrachloride along with watermelon juice or ursodeoxycolic acid (UDCA) significantly reduces these changes. Increased lipid peroxide (LPO) level was observed in the liver, kidney and brain tissues after CCl(4) administration. However, watermelon juice and UDCA treatment prevented the increase in LPO. The results indicated that watermelon juice protects the liver, kidney and brain tissues from experimental CCl(4) toxicity in rats and that the protective effect of watermelon juice may be due to its antioxidant activity and inhibition of lipid peroxide formation. In conclusion, present study reveals biological evidence that supports the use of watermelon juice in the treatment of chemical-induced hepatotoxicity.

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Aspartate Aminotransferases / blood
  • Bilirubin / blood
  • Brain / drug effects
  • Brain / metabolism
  • Brain / pathology
  • Carbon Tetrachloride / toxicity*
  • Citrullus*
  • Kidney / drug effects
  • Kidney / metabolism
  • Lipid Peroxidation / drug effects
  • Liver / drug effects
  • Liver / enzymology
  • Liver / metabolism
  • Liver / pathology
  • Rats


  • Carbon Tetrachloride
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Bilirubin