Nerve excitability properties in early preclinical diabetic neuropathy

Diabetes Res Clin Pract. 2011 Oct;94(1):100-4. doi: 10.1016/j.diabres.2011.06.011. Epub 2011 Jul 8.


Diabetic polyneuropathy can be easily diagnosed when the nerve conduction studies are affected. Strength Duration Time (SDTc) reflects nerve excitability properties and was previously used several times to demonstrate the excitability properties of the nerves in the existence of electrophysiologically developed diabetic polyneuropathy. But as we all know, diabetic patients may experience neuropathic symptoms even though their routine nerve conduction studies are normal. SDTc may be useful in this early stages of developing neuropathy. In this study we aimed to evaluate the SDTc properties of diabetic patients in this early preclinic stage. Recently SDTc was commonly studied in the upper extremities but most of the diabetic neuropathies are predominant in the lower extremities. So here we also studied both upper and lower extremities to demonstrate a possible difference.

MeSH terms

  • Adult
  • Diabetic Neuropathies / physiopathology*
  • Electrophysiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neural Conduction / physiology
  • Polyneuropathies / physiopathology*