Improved diagnostic and prognostic performance of a new high-sensitive troponin T assay in patients with acute coronary syndrome

Am Heart J. 2011 Jul;162(1):81-8. doi: 10.1016/j.ahj.2011.04.007.


Background: In the present study, we aimed to analyze the diagnostic and prognostic potential of a newly developed high-sensitive troponin T assay and compared these results with those of a contemporary troponin T assay in 2 distinct patient cohorts, one including patients with evident ACS and the other one including patients with general chest pain.

Methods and results: For this study, we analyzed data from 2 independent patient cohorts, the Bad Nauheim ACS registry and the Prognosis in Acute Coronary Syndromes registry, with a total of 2,506 patients. On admission, clinical data have been recorded, and a single measurement of troponin T has been performed with a contemporary assay (TnT) and a new high-sensitive troponin T assay (hsTnT). Clinical follow-up has been obtained after 6 months. The diagnostic value of hsTnT was superior to TnT (area under the receiver operating characteristic curve 0.949 vs 0.929, P = .016). Specifically, in TnT-negative patients, hsTnT provided strong diagnostic information (area under the receiver operating characteristic curve of 0.81, P < .001). Furthermore, hsTnT provided independent prognostic power for mortality within 6 months in both cohorts, which was superior to that of the contemporary TnT assay.

Conclusion: Troponin T measured with a newly developed hsTnT provides better diagnostic and prognostic information and, therefore, should be implemented as a standard test in clinical routine.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Coronary Syndrome / blood
  • Acute Coronary Syndrome / diagnosis*
  • Aged
  • Biomarkers / blood*
  • Diagnosis, Differential
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoassay
  • Male
  • Middle Aged
  • Prognosis
  • ROC Curve
  • Registries
  • Retrospective Studies
  • Severity of Illness Index
  • Troponin T / blood*


  • Biomarkers
  • Troponin T