ARDS Network (NHLBI) studies: successes and challenges in ARDS clinical research

Crit Care Clin. 2011 Jul;27(3):459-68. doi: 10.1016/j.ccc.2011.05.011.


To hasten the development of effective therapy for acute respiratory distress syndrome (ARDS), in 1994, the National Heart, Lung, and Blood Institute initiated a clinical network to carry out multicenter clinical trials of ARDS treatments. The ARDS Network is a clinical research network of approximately 42 hospitals, organized into 12 clinical sites. The goal of the Network is to efficiently test promising agents, devices, or management strategies to improve the care of patients with ARDS. Comprehensive information regarding all completed and ongoing ARDSNet clinical trials is available at, but a brief summary is provided in this article.

MeSH terms

  • Acute Lung Injury / drug therapy
  • Acute Lung Injury / therapy*
  • Biomedical Research / organization & administration*
  • Humans
  • Multicenter Studies as Topic
  • National Heart, Lung, and Blood Institute (U.S.) / organization & administration*
  • Randomized Controlled Trials as Topic
  • Respiratory Distress Syndrome / drug therapy
  • Respiratory Distress Syndrome / therapy*
  • United States