Independent recruitment of an O-methyltransferase for syringyl lignin biosynthesis in Selaginella moellendorffii

Plant Cell. 2011 Jul;23(7):2708-24. doi: 10.1105/tpc.110.081547. Epub 2011 Jul 8.

Abstract

Syringyl lignin, an important component of the secondary cell wall, has traditionally been considered to be a hallmark of angiosperms because ferns and gymnosperms in general lack lignin of this type. Interestingly, syringyl lignin was also detected in Selaginella, a genus that represents an extant lineage of the most basal of the vascular plants, the lycophytes. In angiosperms, syringyl lignin biosynthesis requires the activity of ferulate 5-hydroxylase (F5H), a cytochrome P450-dependent monooxygenase, and caffeic acid/5-hydroxyferulic acid O-methyltransferase (COMT). Together, these two enzymes divert metabolic flux from the biosynthesis of guaiacyl lignin, a lignin type common to all vascular plants, toward syringyl lignin. Selaginella has independently evolved an alternative lignin biosynthetic pathway in which syringyl subunits are directly derived from the precursors of p-hydroxyphenyl lignin, through the action of a dual specificity phenylpropanoid meta-hydroxylase, Sm F5H. Here, we report the characterization of an O-methyltransferase from Selaginella moellendorffii, COMT, the coding sequence of which is clustered together with F5H at the adjacent genomic locus. COMT is a bifunctional phenylpropanoid O-methyltransferase that can methylate phenylpropanoid meta-hydroxyls at both the 3- and 5-position and function in concert with F5H in syringyl lignin biosynthesis in S. moellendorffii. Phylogenetic analysis reveals that Sm COMT, like F5H, evolved independently from its angiosperm counterparts.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism
  • Cell Wall / chemistry
  • Cell Wall / metabolism
  • Cell Wall / ultrastructure
  • Gene Expression Regulation, Plant
  • Genetic Complementation Test
  • Lignin / biosynthesis*
  • Lignin / chemistry
  • Magnoliopsida / enzymology
  • Methyltransferases / classification
  • Methyltransferases / genetics
  • Methyltransferases / metabolism*
  • Models, Molecular
  • Molecular Sequence Data
  • Molecular Structure
  • Phylogeny
  • Plant Proteins / classification
  • Plant Proteins / genetics
  • Plant Proteins / metabolism*
  • Plants, Genetically Modified / enzymology
  • Plants, Genetically Modified / genetics
  • Protein Structure, Tertiary
  • Selaginellaceae / anatomy & histology
  • Selaginellaceae / enzymology*
  • Sequence Alignment
  • Tissue Distribution

Substances

  • Arabidopsis Proteins
  • Plant Proteins
  • syringyl monolignol
  • Lignin
  • Methyltransferases
  • caffeate O-methyltransferase