Abstract
The kinetics of alpha 1-adrenergic response to noradrenaline was studied in isolated epididymal section of the rat vas deferens. Two discrete pools of alpha 1-adrenoreceptors differing by their affinity to noradrenaline, were revealed. The alpha 1-adrenoreceptors also differed from each other in their ability to interact with one or two molecules of the transmitter. Functional role of heterogeneity of the receptors is discussed.
MeSH terms
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Animals
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Dose-Response Relationship, Drug
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In Vitro Techniques
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Kinetics
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Male
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Muscle Contraction / drug effects
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Muscle Contraction / physiology
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Muscle, Smooth / drug effects
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Muscle, Smooth / physiology*
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Norepinephrine / pharmacology
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Rats
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Rats, Inbred Strains
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Receptors, Adrenergic, alpha / drug effects
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Receptors, Adrenergic, alpha / physiology*
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Vas Deferens / drug effects
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Vas Deferens / physiology
Substances
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Receptors, Adrenergic, alpha
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Norepinephrine