[A kinetic analysis of the alpha 1-adrenergic reaction of the smooth muscles in the rat vas deferens]

Fiziol Zh SSSR Im I M Sechenova. 1990 Jul;76(7):863-8.
[Article in Russian]

Abstract

The kinetics of alpha 1-adrenergic response to noradrenaline was studied in isolated epididymal section of the rat vas deferens. Two discrete pools of alpha 1-adrenoreceptors differing by their affinity to noradrenaline, were revealed. The alpha 1-adrenoreceptors also differed from each other in their ability to interact with one or two molecules of the transmitter. Functional role of heterogeneity of the receptors is discussed.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • In Vitro Techniques
  • Kinetics
  • Male
  • Muscle Contraction / drug effects
  • Muscle Contraction / physiology
  • Muscle, Smooth / drug effects
  • Muscle, Smooth / physiology*
  • Norepinephrine / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Adrenergic, alpha / drug effects
  • Receptors, Adrenergic, alpha / physiology*
  • Vas Deferens / drug effects
  • Vas Deferens / physiology

Substances

  • Receptors, Adrenergic, alpha
  • Norepinephrine