Endothelial dysfunction in the regulation of cirrhosis and portal hypertension

Liver Int. 2012 Feb;32(2):199-213. doi: 10.1111/j.1478-3231.2011.02579.x. Epub 2011 Jul 5.


Portal hypertension is caused by an increased intrahepatic resistance, a major consequence of cirrhosis. Endothelial dysfunction in liver sinusoidal endothelial cells (LSECs) decreases the production of vasodilators, such as nitric oxide, and favours vasoconstriction. This contributes to an increased vascular resistance in the intrahepatic/sinusoidal microcirculation and develops portal hypertension. Portal hypertension, in turn, causes endothelial dysfunction in the extrahepatic, i.e. splanchnic and systemic, circulation. Unlike dysfunction in LSECs, endothelial dysfunction in the splanchnic and systemic circulation causes overproduction of vasodilator molecules, leading to arterial vasodilation. In addition, portal hypertension leads to the formation of portosystemic collateral vessels. Both arterial vasodilation and portosystemic collateral vessel formation exacerbate portal hypertension by increasing the blood flow through the portal vein. Pathological consequences, such as oesophageal varices and ascites, result. While the sequence of pathological vascular events in cirrhosis and portal hypertension has been elucidated, the underlying cellular and molecular mechanisms causing endothelial dysfunctions are not yet fully understood. This review article summarizes the current cellular and molecular studies on endothelial dysfunctions found during the development of cirrhosis and portal hypertension with a focus on the intra- and extrahepatic circulations. The article ends by discussing the future directions of the study for endothelial dysfunction.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Ascites / etiology
  • Ascites / pathology
  • Ascites / physiopathology
  • Collateral Circulation
  • Endothelial Cells / metabolism
  • Endothelial Cells / pathology*
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / pathology*
  • Endothelium, Vascular / physiopathology
  • Esophageal and Gastric Varices / etiology
  • Esophageal and Gastric Varices / pathology
  • Esophageal and Gastric Varices / physiopathology
  • Humans
  • Hypertension, Portal / complications
  • Hypertension, Portal / pathology*
  • Hypertension, Portal / physiopathology
  • Liver / blood supply
  • Liver / pathology*
  • Liver / physiopathology
  • Liver Circulation
  • Liver Cirrhosis / complications
  • Liver Cirrhosis / pathology*
  • Liver Cirrhosis / physiopathology
  • Neovascularization, Pathologic / etiology
  • Neovascularization, Pathologic / pathology
  • Neovascularization, Pathologic / physiopathology
  • Vasodilator Agents / metabolism


  • Vasodilator Agents