Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats

Lipids Health Dis. 2011 Jul 12;10:116. doi: 10.1186/1476-511X-10-116.

Abstract

Background: Recent studies have reported the preventive effects of probiotics on obesity. Among commensal bacteria, bifidobacteria is one of the most numerous probiotics in the mammalian gut and are a type of lactic acid bacteria. The aim of this study was to assess the antiobesity and lipid-lowering effects of Bifidobacterium spp. isolated from healthy Korean on high fat diet-induced obese rats.

Methods: Thirty-six male Sprague-Dawley rats were divided into three groups as follows: (1) SD group, fed standard diet; (2) HFD group, fed high fat diet; and (3) HFD-LAB group, fed high fat diet supplemented with LAB supplement (B. pseudocatenulatum SPM 1204, B. longum SPM 1205, and B. longum SPM 1207; 108 ~ 109 CFU). After 7 weeks, the body, organ, and fat weights, food intake, blood serum levels, fecal LAB counts, and harmful enzyme activities were measured.

Results: Administration of LAB reduced body and fat weights, blood serum levels (TC, HDL-C, LDL-C, triglyceride, glucose, leptin, AST, ALT, and lipase levels), and harmful enzyme activities (β-glucosidase, β-glucuronidase, and tryptophanase), and significantly increased fecal LAB counts.

Conclusion: These data suggest that Bifidobacterium spp. used in this study may have beneficial antiobesity effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Anti-Obesity Agents / pharmacology*
  • Aspartate Aminotransferases / blood
  • Bifidobacterium*
  • Blood Glucose
  • Dietary Fats
  • Feces / enzymology
  • Feces / microbiology
  • Glucuronidase / metabolism
  • Hypolipidemic Agents / pharmacology*
  • Leptin / blood
  • Lipase / blood
  • Lipids / blood
  • Male
  • Obesity / blood
  • Obesity / chemically induced
  • Obesity / prevention & control*
  • Probiotics / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Tryptophanase / metabolism
  • Urease / metabolism
  • Weight Gain / drug effects
  • alpha-Amylases / blood
  • beta-Glucosidase / metabolism

Substances

  • Anti-Obesity Agents
  • Blood Glucose
  • Dietary Fats
  • Hypolipidemic Agents
  • Leptin
  • Lipids
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Lipase
  • alpha-Amylases
  • beta-Glucosidase
  • Glucuronidase
  • Urease
  • Tryptophanase