Chronic cerebrospinal venous insufficiency and multiple sclerosis

Arch Neurol. 2011 Nov;68(11):1379-84. doi: 10.1001/archneurol.2011.179. Epub 2011 Jul 11.


Chronic cerebrospinal venous insufficiency has recently been proposed to be etiologic to multiple sclerosis. Independent investigation into this theory during the past 2 years has not succeeded in verifying this relationship. A critical analysis of the scientific methods used in the original studies of chronic cerebrospinal venous insufficiency in multiple sclerosis reveals several methodological problems with regard to potential bias and confounding. The current evidence calls into question whether chronic cerebrospinal venous insufficiency in multiple sclerosis exists at all.

Publication types

  • Review

MeSH terms

  • Animals
  • Cerebral Veins / physiopathology*
  • Chronic Disease
  • Clinical Trials as Topic / methods
  • Humans
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / etiology
  • Multiple Sclerosis / physiopathology*
  • Regional Blood Flow / physiology
  • Spinal Cord / blood supply*
  • Venous Insufficiency / complications
  • Venous Insufficiency / epidemiology
  • Venous Insufficiency / physiopathology*