A facile, modular and high yield method to assemble three-dimensional DNA structures

Chem Commun (Camb). 2011 Aug 21;47(31):8925-7. doi: 10.1039/c1cc11726b. Epub 2011 Jul 11.


We describe a rapid and quantitative method to generate DNA cages of deliberately designed geometry from readily available starting strands. Balancing the incorporation of sequence uniqueness and symmetry in a face-centered approach to 3D construction can result in triangular (TP), rectangular (RP), and pentagonal prisms (PP) without compromising the potential for nanostructure addressability.

MeSH terms

  • DNA / chemistry*
  • Nanostructures / chemistry
  • Nucleic Acid Conformation
  • Temperature


  • DNA