The metabolic fate of isocombretastatin A-4 in human liver microsomes: identification, synthesis and biological evaluation of metabolites

ChemMedChem. 2011 Oct 4;6(10):1781-8. doi: 10.1002/cmdc.201100193. Epub 2011 Jul 11.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemical synthesis
  • Antineoplastic Agents, Phytogenic / metabolism*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Line, Tumor
  • Humans
  • Hydroxylation
  • Isomerism
  • Microsomes, Liver / metabolism*
  • Stilbenes / chemistry
  • Stilbenes / metabolism*
  • Stilbenes / pharmacology
  • Tubulin / drug effects
  • Tubulin Modulators / chemical synthesis
  • Tubulin Modulators / metabolism*
  • Tubulin Modulators / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Stilbenes
  • Tubulin
  • Tubulin Modulators
  • fosbretabulin