A DTaP-IPV//PRP∼T vaccine (Pentaxim): a review of 16 years' clinical experience

Expert Rev Vaccines. 2011 Jul;10(7):981-1005. doi: 10.1586/erv.11.72. Epub 2011 Jul 12.


Owing to their low reactogenicity, confirmed efficacy and availability in combination vaccines, acellular pertussis (aP)-inactivated poliovirus (IPV) combined vaccines are now included in various national immunization programs worldwide. We provide an overview of 16 years of clinical experience with a diphtheria (D), tetanus (T), aP, IPV and Haemophilus influenzae type b (Hib) polysaccharide conjugated to tetanus protein (PRP∼T) combined vaccine (DTaP-IPV//PRP∼T - Pentaxim, Sanofi Pasteur, France). Good immunogenicity has been demonstrated after primary vaccination with Pentaxim, regardless of the population ethnicity and primary vaccination schedule. A booster vaccination in the second year of life also resulted in a high immune response for each antigen. Furthermore, 10 years of national surveillance in Sweden has demonstrated the effectiveness of Pentaxim in controlling pertussis. As is the case for other aP-containing combined vaccines, Pentaxim is well tolerated, with the safety profile being better than for whole-cell pertussis-containing combination vaccines for primary and booster vaccinations.

Publication types

  • Review

MeSH terms

  • Child
  • Child, Preschool
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / administration & dosage
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / adverse effects
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / immunology*
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / therapeutic use
  • Haemophilus Vaccines / administration & dosage
  • Haemophilus Vaccines / adverse effects
  • Haemophilus Vaccines / immunology*
  • Haemophilus Vaccines / therapeutic use
  • Humans
  • Immunization Schedule
  • Infant
  • Infant, Newborn
  • Sweden
  • Tetanus Toxoid / administration & dosage
  • Tetanus Toxoid / adverse effects
  • Tetanus Toxoid / immunology*
  • Tetanus Toxoid / therapeutic use
  • Vaccination
  • Vaccines, Combined / administration & dosage
  • Vaccines, Combined / adverse effects
  • Vaccines, Combined / immunology
  • Vaccines, Combined / therapeutic use
  • Vaccines, Conjugate / administration & dosage
  • Vaccines, Conjugate / adverse effects
  • Vaccines, Conjugate / immunology*
  • Vaccines, Conjugate / therapeutic use


  • Diphtheria-Tetanus-acellular Pertussis Vaccines
  • Haemophilus Vaccines
  • Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate
  • Tetanus Toxoid
  • Vaccines, Combined
  • Vaccines, Conjugate