Inhibitory effect of antineoplaston A-10 on breast cancer transplanted to athymic mice and human hepatocellular carcinoma cell lines. The members of Antineoplaston Study Group

Kurume Med J. 1990;37(2):97-104. doi: 10.2739/kurumemedj.37.97.

Abstract

The inhibitory effect of Antineoplaston A-10 was tested on the growth curve of human breast cancer (R-27) serially transplanted to athymic mice and on the cell growth of human hepatocellular carcinomas (KMCH-1, KYN-1, KIM-1). Approximately 1.25% of Antineoplaston A-10 in the regular mouse diet (CE2) inhibited the growth curve significantly after 35 days treatment (p less than 0.05). Seventy milligrams of daily intraperitoneal administration of Antineoplaston A-10 Injection also inhibited the growth curve of R-27 after 52 days treatment (p less than 0.01). Histological study of tumor showed no essential difference in structure but significant decrease in number of mitoses in the Antineoplaston A-10 treated groups. The cell growth of human hepatocellular carcinoma cell lines KMCH-1, KYN-1 and KIM-1 was inhibited by Antineoplaston A-10 Injection dose dependently.

MeSH terms

  • Administration, Oral
  • Animals
  • Benzeneacetamides*
  • Carcinoma, Hepatocellular / pathology*
  • Female
  • Humans
  • Liver Neoplasms / pathology*
  • Mammary Neoplasms, Experimental / drug therapy*
  • Mice
  • Mice, Inbred BALB C
  • Neoplasm Transplantation
  • Piperidines / administration & dosage
  • Piperidines / pharmacology*
  • Piperidines / therapeutic use
  • Piperidones*
  • Transplantation, Heterologous
  • Tumor Cells, Cultured / drug effects

Substances

  • Benzeneacetamides
  • Piperidines
  • Piperidones
  • antineoplaston A10