Phosphatases: providing safe passage through mitotic exit

Nat Rev Mol Cell Biol. 2011 Jul 13;12(8):469-82. doi: 10.1038/nrm3149.

Abstract

The mitosis-to-interphase transition involves dramatic cellular reorganization from a state that supports chromosome segregation to a state that complies with all functions of an interphase cell. This process, termed mitotic exit, depends on the removal of mitotic phosphorylations from a broad range of substrates. Mitotic exit regulation involves inactivation of mitotic kinases and activation of counteracting protein phosphatases. The key mitotic exit phosphatase in budding yeast, Cdc14, is now well understood. By contrast, in animal cells, it is now emerging that mitotic exit relies on distinct regulatory networks, including the protein phosphatases PP1 and PP2A.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Aurora Kinases
  • CDC2 Protein Kinase / physiology
  • Cell Cycle / physiology
  • Cell Cycle Proteins / physiology
  • Cyclin B1 / physiology
  • Humans
  • Interphase / physiology
  • Mitosis / physiology*
  • Models, Biological
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Phosphoric Monoester Hydrolases / physiology*
  • Protein Phosphatase 1 / physiology
  • Protein Phosphatase 2 / physiology
  • Protein Tyrosine Phosphatases / physiology
  • Protein-Serine-Threonine Kinases / physiology
  • Proto-Oncogene Proteins / physiology
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / physiology
  • Saccharomyces cerevisiae Proteins / physiology
  • Ubiquitin-Protein Ligase Complexes / physiology

Substances

  • CDC14 protein, S cerevisiae
  • Cell Cycle Proteins
  • Cyclin B1
  • Proto-Oncogene Proteins
  • Saccharomyces cerevisiae Proteins
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases
  • polo-like kinase 1
  • CDC2 Protein Kinase
  • Protein Phosphatase 1
  • Protein Phosphatase 2
  • Phosphoric Monoester Hydrolases
  • Protein Tyrosine Phosphatases