In Situ Remineralization of White-Spot Enamel Lesions by 500 and 1,100 PPM F Dentifrices

Clin Oral Investig. 2012 Aug;16(4):1007-14. doi: 10.1007/s00784-011-0591-2. Epub 2011 Jul 13.

Abstract

The aim of this study was to evaluate the remineralization potential of three silica-containing NaF dentifrice systems in an intraoral model. Subjects (N = 30) in this randomized, three-phase, 28-day, crossover study served as their own control. Each participant wore a customized orthodontic appliance attached to a mandibular molar and contained one tooth block with caries-like lesion. For each phase, participants engaged in twice-daily brushing for 2 min with one of the following dentifrices: 500 ppm F, 500 ppm F plus functionalized β-tricalcium phosphate (fTCP), and a clinically proven 1,100 ppm F. After each phase, appliances were removed, and specimens were analyzed using surface microhardness (SMH), transverse microradiography (TMR), and cross-sectional microhardness (CSMH). Statistically significant (p < 0.05) remineralization of white-spot lesions relative to baseline occurred for each dentifrice as determined with SMH and TMR. No significant differences (p > 0.05) in SMH were found among the three groups, but trending revealed the 500 ppm F plus fTCP produced 26% and 27% greater SMH recovery relative to 500 and 1,100 ppm F, respectively. Similarly, no significant differences (p > 0.05) in TMR were found among the groups. However, the 500 ppm F plus fTCP dentifrice produced 10% and 38% greater mineral recovery relative to 500 and 1,100 ppm F, respectively, while reducing the lesion depth 30% and 52%, respectively. Significant differences (p < 0.05) in CSMH existed among the three dentifice groups at different enamel depths, but statistical differences (p < 0.05) in relative lesion size were only found between 500 ppm F plus fTCP and 500 ppm F. The combination of fTCP and fluoride in a single-compartment, water-based dentifrice can cooperate with fluoride to produce significant remineralization. These results suggest that the combination of 500 ppm F with fTCP may provide comparable anticaries benefits relative to a 1,100 ppm F dentifrice.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Biocompatible Materials / administration & dosage
  • Biocompatible Materials / therapeutic use
  • Calcium Phosphates / administration & dosage
  • Calcium Phosphates / therapeutic use
  • Cariostatic Agents / administration & dosage
  • Cariostatic Agents / therapeutic use*
  • Cross-Over Studies
  • Dental Caries / pathology
  • Dental Caries / therapy*
  • Dental Enamel / drug effects*
  • Dental Enamel / pathology
  • Dentifrices / therapeutic use*
  • Female
  • Hardness
  • Humans
  • Male
  • Microradiography
  • Middle Aged
  • Minerals / analysis
  • Silicic Acid / administration & dosage
  • Silicic Acid / therapeutic use
  • Sodium Fluoride / administration & dosage
  • Sodium Fluoride / therapeutic use*
  • Tooth Remineralization / methods*
  • Toothbrushing / methods
  • Toothpastes / administration & dosage
  • Toothpastes / therapeutic use
  • Young Adult

Substances

  • Biocompatible Materials
  • Calcium Phosphates
  • Cariostatic Agents
  • Dentifrices
  • Minerals
  • Toothpastes
  • beta-tricalcium phosphate
  • hydrated silica gel-based toothpaste
  • Silicic Acid
  • Sodium Fluoride